Evaluation of tumor M2-pyruvate kinase (Tumor M2-PK) as a biomarker for pancreatic cancer
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منابع مشابه
Evaluation of tumor M2-pyruvate kinase (Tumor M2-PK) as a biomarker for pancreatic cancer
BACKGROUND Expression of the dimeric M2 isoenzyme of pyruvate kinase, termed Tumor M2-PK, is increased in some human cancers. This study evaluates the potential role of pre-operative Tumor M2-PK as a marker of prognosis in patients with pancreatic malignancy. METHODS Seventy-three consecutive patients with a clinical diagnosis of pancreatic or peri-ampullary cancer were enrolled. Their median...
متن کاملFecal pyruvate kinase-M2 (tumor M2-PK) measurement: a new screening concept for colorectal cancer.
BACKGROUND Colorectal cancer (CRC) is a disease with major impact on public health and public health costs. Colonoscopy is purportedly the best screening tool for CRC. However, the acceptance by the general population is very poor. Therefore evaluation of additional screening tools is of great interest. PATIENTS AND METHODS The use of M2-PK measurement in the feces has been reported in 6 stud...
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Various isoforms of the glycolytic enzyme pyruvate kinase are expressed in different cell types. One of these isoforms, Tu M2-PK, is over-expressed in tumor cells and released into body fluids. Plasma determination of Tu M2-PK has been shown to discriminate between benign and malignant lesions. Tu M2-PK was quantitated in the plasma of 50 patients with cervical carcinoma, 10 patients with chron...
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Pyruvate kinase M2 (PKM2) has been studied for decades on its role in cancer metabolism. Re-cently, PKM2 is highlighted again for its new function: promoting gene transcription by acting as a pro-tein kinase. Moreover, the PKM2 levels in patient circulation have been used as a diagnostic marker formany types of cancers. However, it remains unclear whether PKM2 in blood circulati...
متن کاملThe value of fecal tumor M2 pyruvate kinase as a diagnostic tool for colorectal cancer screening.
AIM to evaluate the performance of fecal tumor M2 pyruvate kinase (M2PK) as a diagnostic biomarker for colorectal cancer (CRC) screening in high-risk or symptomatic populations. METHODS consecutive patients (N=328) who were referred for elective colonoscopy were prospectively enrolled. One walnut-sized stool sample was collected from each patient for analysis of tumor M2PK content using an EL...
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ژورنال
عنوان ژورنال: World Journal of Surgical Oncology
سال: 2018
ISSN: 1477-7819
DOI: 10.1186/s12957-018-1360-3